The Glyph client is a cluster fuck of memory leaks and as such is a resource hog. When you hit the play button and the leaf comes up and starts to populate the text, kill the Glyph program.

Play in native resolution with windowed mode on and Direct 9x checked. Keep shadows off and all the water particle effects to minimum. Turn down terrain detail and distance to render flora/fauna.

I have a monster rig and the Glyph program was sucking up to 45% of available memory after about an hour of memory leaks.

Don't make me have'ta Troll ya Bro!