I have both.
1. I like the ergonomics better, but it doesn't have as many keys as the G13. The G13 is fine, I just have to stretch to get those corner keys, but I just use those for rarely used functions.

Aside from that, the G13 is much better and much more flexible in programming. I still use my N52TE, but for my bot computer.

It took me a while to get used to my N52 and I was loving it. Then I got the G13 and it took me a while to get used to that, even after having used the N52. As far as I am concerned, the G13 is the primo game pad out there right now.