IMO the newb quests are worth it up til the bone knight quest. It gets you used to the GUI, a decent amount of $$ - 300 or so through the first 10 quests. It gets you some weapons, tools, bags, armor etc. I would say do them and then head over to the city. I would also say to avoid a lot of frustration in the newb towns - do not join the guild until you are done and heading towards the city. That is when you should guild up.

I need to go hand in a quest in Shoal so if you need help let me know and I will head over there next time I get a chance.