What mouse do you use?

I find a mouse with lots of buttons and with a scroll wheel that can be clicked left and right when combined with a few modifier keys on the keyboard can give you easy access to many skills without moveing your hands.

ie you can have mousewheel left = fast heal, mousewheel right = big heal, side mouse button = HoT.

Shift + mousewheel left = fast cast damage spell, shift + mousewheel right = big slow cast damage spell, shift + side mouse button = insta cast dot.

So you can have double figures of hot keyed skills that are accessable without moving your hand from the mouse or your fingers off WASD.

Pushing the scrollwheel in is also a button but I don't find that hugely easy to do so I bind it to something rare but that you would want fast access too.

I use a logitech G5 mouse and a G15 keyboard, mine has 18 G macro keys and 3 buttons that change what these buttons do giving you turns of customisation.