The downtime can be irritating. There are ways to heavily mitigate it, but they require a good deal of initial work/planning, like getting insta-jump bookmarks and planning your skills and logistics etc.

Great game though. I'll probably reactivate some accounts sooner or later, Im more in an FPS type mood lately and EVE can play slow. But yeah as far as Economic/PvP/PK/Guild Battles etc, its probably the best game on the market right now.